ACTTION:  Optimizing trials, promoting collaborations, in the development of novel therapeutics

Effective July 1, 2011, IMMPACT consensus meetings, publications, and other activities will be conducted under the auspices of the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the United States Food and Drug Administration. Link here for more information on the organization, resources, and publications.  Learn more:

American Academy of Pain Medicine

The American Academy of Pain Medicine (AAPM) is the medical specialty society representing physicians and their team members practicing in the field of pain medicine. As a medical specialty society, the Academy is involved in education, training, advocacy, and research in the specialty of pain medicine.

BMC Health Services Research

BMC Health Services Research is an open access, peer-reviewed journal that considers articles on all aspects of health services research, including delivery of care, management of health services, assessment of healthcare needs, measurement of outcomes, allocation of healthcare resources, evaluation of different health markets and health services organizations, international comparative analysis of health systems, health economics and the impact of health policies and regulations.

Centers for Disease Control and Prevention (CDC)

As the nation’s health protection agency, CDC saves lives and protects people from health threats. To accomplish our mission, CDC conducts critical science and provides health information that protects our nation against expensive and dangerous health threats, and responds when these arise.

Clinical Practice Guideline for Diagnosis and Treatment of Low Back Pain (LBP) (2017)

The guideline developed by the VA/DoD is intended to improve patient outcomes and local management of patients with low back pain. It describes the critical decision points in the diagnosis and Management of Low Back Pain (LBP) and provides clear and comprehensive evidence based recommendations.  Learn more:

Clinical Practice Guidelines (CPG) Policy Guidance

VA Evidence-Based Practice works with the Department of Defense (DoD) to develop evidence-based practice guidelines to be used within the VA and DoD.

CPG for Management of Opioid Therapy (OT) for Chronic Pain (2017)

The guideline describes the critical decision points in the Management of Opioid Therapy (OT) for Chronic Pain and provides clear and comprehensive evidence based recommendations incorporating current information and practices for practitioners throughout the DoD and VA Health Care systems. The workgroup consensus statements are provided to minimize harm and increase patient safety in patients requiring opioid therapy.

Disclaimer:This Clinical Practice Guideline is intended for use only as a tool to assist a clinician/healthcare professional and should not be used to replace clinical judgment.

More information:

IMMPACT:  Improving our understanding of pain and its treatment

The Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) was established in 2002 to develop consensus reviews and recommendations for improving the design, execution, and interpretation of clinical trials of treatments for pain. Link here for more information on this initiative, including a resource list of IMMPACT consensus recommendations, systematic reviews, and research studies.  Learn more:

The National Academies of Sciences, Engineering, and Medicine

The National Academies of Sciences, Engineering, and Medicine produce groundbreaking reports that have helped shape sound policies, inform public opinion, and advance the pursuit of science, engineering, and medicine.

NIH HEAL Inititiative

In April 2018, NIH launched the HEAL (Helping to End Addiction Long-term) Initiative, an aggressive, trans-agency effort to speed scientific solutions to stem the national opioid public health crisis. This Initiative will build on extensive, well-established NIH research, including basic science of the complex neurological pathways involved in pain and addiction, implementation science to develop and test treatment models, and research to integrate behavioral interventions with Medication-Assisted Treatment (MAT) for opioid use disorder (OUD).

For HEAL Initiative funding announcements and opportunities, click here

Rethinking Clinical Trials:  A Living Textbook of Pragmatic Clinical Trials

The Mission of the NIH Collaboratory of Pragmatic Clinical Trials is to “strengthen the national capacity to implement cost-effective large-scale research studies that engage healthcare delivery organizations as research partners.” For more information on this groundbreaking initiative click here:

Translational Research Institute for Pain in Later Life (TRIPLL)

The Translational Research Institute for Pain in Later Life (TRIPLL) is an NIA funded Edward R. Roybal center with a focus on chronic pain. TRIPLL was established in response to the plight of millions of older adults experiencing persistent pain, a costly and frequently disabling disorder in later life. Effective solutions to the problem of later-life pain require moving basic behavioral and social science and medical research findings more rapidly into programs, practices and policies targeting older adults. TRIPLL supports translational research in aging in the NYC area.

VA/DoD Clinical Practice Guidelines (CPG)

The Veterans Affairs and Department of Defense Health Care Systems have long been identified as leaders in clinical practice guideline development. This landing page is a valuable resource for best practices and other resources:

Veterans Health Administration (VHA) Pain Management

The Veterans Health Administration (VHA) Pain Management homepage providing pain management resources for Veterans, Veterans' family members, caregivers, VA administrators, clinicians, and researchers.