Supporting Research in Pain Management for Veterans and Military Service Members

Analysis of “learn-as-you-go” (LAGO) studies

Daniel Nevo, Judith J. Lok, Donna Spiegelman
The Annals of Statistics
2021, Vol. 49, No. 2, 793–819

What are ways that investigators can plan for study design changes as data accumulates? The authors present Learn-As-you-GO (LAGO) for an adaptive method to apply in stages during a study, and compare against other adaptive designs for trials such as Sequential Multiple Assignment Randomized Trial (SMART) design and Multiphase Optimization Strategy (MOST). Methods are illustrated through the Better Birth Study.

Full Citation

Daniel Nevo. Judith J. Lok. Donna Spiegelman. “Analysis of “learn-as-you-go” (LAGO) studies.” Ann. Statist. 49 (2) 793 – 819, April 2021. https://doi.org/10.1214/20-AOS1978

The goal of the Collaboratory is to develop the capacity to implement cost-effective large-scale pragmatic clinical research in military and veteran health care delivery organizations focusing on nonpharmacological approaches to pain management and other comorbid conditions.

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