Daniel Nevo, Judith J. Lok, Donna Spiegelman
The Annals of Statistics
2021, Vol. 49, No. 2, 793–819
What are ways that investigators can plan for study design changes as data accumulates? The authors present Learn-As-you-GO (LAGO) for an adaptive method to apply in stages during a study, and compare against other adaptive designs for trials such as Sequential Multiple Assignment Randomized Trial (SMART) design and Multiphase Optimization Strategy (MOST). Methods are illustrated through the Better Birth Study.
Daniel Nevo. Judith J. Lok. Donna Spiegelman. “Analysis of “learn-as-you-go” (LAGO) studies.” Ann. Statist. 49 (2) 793 – 819, April 2021. https://doi.org/10.1214/20-AOS1978