Phenotypes and Outcomes Work Group
Reliable and clinically-actionable phenotyping of patients with pain can inform examination of sociodemographic and clinical characteristics that may moderate treatment effects, especially in non-pharmacological interventions. Harmonization of these domains along with outcome measures and key process variables will help promote more robust meta-analyses and comparisons of pragmatic trial results. The Phenotyping and Outcomes Work Group aims to identify and characterize these important phenotyping features and promote the use of harmonized outcome measures across the pragmatic trials.
Chair or Co-Chairs:
Robert R. Edwards, PhD
Steve Luther, PhD
Project Manager:
Mary Geda
Work Group Goals
- Identify reliable and clinically meaningful phenotypes among participants, for use in examining important treatment effect moderators and for enhanced understanding of study results.
- Promote harmonization of measurement approaches, when feasible, especially for key outcomes proposed.
- Provide a forum for discussing analytic, technical, and regulatory issues that arise related to harmonization of measurement approaches.
Work Group Co-Chairs – Qualifications and Experience
Robert R. Edwards, PhD is an Associate Professor of Anesthesia and a licensed clinical psychologist in the Pain Management Center at Brigham & Women’s Hospital / Harvard Medical School.
Steve Luther, PhD is a Health Services and Informatics Researcher and Assistant Director at the Tampa HSR&D Center of Innovation on Disability and Rehabilitation Research. He is also and Associate Professor at the University of South Florida, College of Public Health, Department of Health Policy and Management. His research interests focus on outcomes, measurement of veteran populations, particularly those with disabilities in chronic condition.
Working Documents & Other Information
Research Tools and Measures
Tools & Measures for Researchers A key objective of the Pain Management Collaboratory (PMC) is to encourage shared learning and data and the identification and...
Read More
Pain Management Collaboratory (PMC) Coronavirus Pandemic Measures
Objectively measuring psychosocial, functional, financial, and lifestyle factors and studying their relationship with outcomes is especially important in studies investigating health conditions, such as pain,...
Read More