Research can help find the optimal pathway to limit the negative impacts of pain.
Research & Researchers
Pain is often a complex problem in that everyone experiences it differently. In western medicine, we have very little pragmatic, clinical research on options for managing it effectively, nonpharmacological or otherwise. Additionally, the opioid epidemic has shown that pharmacological approaches may have only minimal benefit for the management of pain and the risk of substantial harms.
Pragmatic Clinical Trials
Research in Real-World Settings
Work Groups
Data Expertise & Best Practices
Guidance for Study Design and Proposals
Guidance for Study Design & Proposals A selection of publications, tools, and recommendations for developing strong proposals and adaptive studies Publications Presentations More Information Northwestern University’s Dissemination and Implementation Program Northwestern’s Center for Community Health (CCH) and the Center for Prevention Implementation Methodology formed the Dissemination and Implementation Program to provide education, training and consultation to
The Role of Health Informatics in Pain Management
Health informatics brings information to the fingertips of clinician-researchers and practicing clinicians to help with evidence-based care recommendations and improve patient outcomes.
From Our Work Groups
Intraclass Correlation Coefficients for Cluster Randomized Trials with Pain Outcomes
In this working document, the Pain Management Collaboratory Biostatistics/Design Workgroup offers an overview of the intraclass correlation coefficient (ICC) and recommendations for researchers planning cluster randomized trials with pain outcomes.
Prevention of Missing Data in Pragmatic Clinical Trials of Nonpharmacologic Interventions for Pain Management
PMC’s Biostatistics/Design Work Group addresses the problem of missing data in pragmatic clinical trials, and offers a survey of methods that some of PMC’s trials are incorporating to prevent missing data.
Featured Publications
Pain Management Collaboratory: Updates, Lessons Learned, and Future Directions
This supplement shares new knowledge from the Pain Management Collaboratory.
Impact of the COVID-19 Pandemic on Non-Pharmacological Pain Management Trials in Military and Veteran Healthcare Settings
PMC Coordinating Center extends its appreciation to the authors for the impactful research into the the effects of the COVID-19 on non-pharmacological pain management trials in military and veteran healthcare settings. Research done by Amanda Midboe, et al, informs multiple areas of implications.
PMC Publications Listing
The following publications are products of research done within the NIH-DOD-VA Pain Management Collaboratory.
Cognitive Behavioral Therapy for Veterans With Comorbid Posttraumatic Headache and Posttraumatic Stress Disorder Symptoms
This manuscript described the primary outcomes from a CBT-based intervention designed to address headache attributable to mild TBI and comorbid PTSD in Veterans. We found that the CBT headache intervention produced headache outcomes that were superior to medical management in VA polytrauma and PTSD outcomes comparable to Cognitive Processing Therapy.
Confronting Racism in All Forms of Pain Research: A Shared Commitment for Engagement, Diversity, and Dissemination
The third paper in the three-part series on addressing racism in pain research, the authors advocate for a shared commitment toward an antiracism framework in pain research. They identify community partnerships, diversification of research environments, and changes to dissemination practices.
Confronting Racism in All Forms of Pain Research: Reframing Study Designs
This second paper in a 3-part series on antiracism in pain research across the translational spectrum focuses on study design factors.
