A key objective of the Pain Management Collaboratory (PMC) is to encourage shared learning and data and the identification and optimization of best practices in the design and enactment of the PMC pragmatic clinical trials (PCTs). In this context, the PMC community has come together to develop a core set of measures of key phenotypes and outcomes that can be applied across the PCTs. These measures were comprehensively reviewed and recommended by the PMC Phenotypes and Outcomes Work Group and are endorsed by the PMC Steering Committee, which includes the PMC³ leadership, representatives from the sponsoring agencies, and the principal investigators of the PCTs.